The Role of Lithium in Pathogenesis of Bronchial Asthma on the Basis of Studying its Effect on Regulation of Neuro-Immuno-Endocrine Systems

Eka Rodonaia, Tamaz Churadze

The aim of presented work was to consider the role of lithium in pathogenesis of bronchial asthma on the basis of studying its effect on regulation of Neuro-Immuno-Endocrine systems. In order to correct errors in the systems the effective method of treatment has been devised. 80 children aged 1-14 years suffering from bronchial asthma have been investigated. All the patients were homogeneous according to their demographic-anamnetic data and studied parameters. Decrease in concentration of lithium ions was registered at the onset of the disease. Dispersal analysis (ANOVA-oneway) revealed existence of statistically reliable correlation between severity of the disease and content of lithium ions - in particular, as severe the disease was, the lower concentration of lithium ions was observed. As a result of basis therapy, concentration of lithium ions remained constant indicating chronisation of the process. It can also be considered as a reason for further relapse. To inhibit the mechanisms leading to the destruction of membranes and to correct abnormalities in Neuro-Immuno-Endocrine regulatory system, lithium carbonate was tested in medical treatment. A new scheme for effective treatment in hospital conditions has been worked out that provides for using lithium carbonate in complex basis therapy under regular control on lithium ions concentration in blood.

Keywords:   neuro- immuno- endocrine system, bronchial asthma, lithium