Immunomorphological Peculiarities of Spleen According to Microbial State and Age of Body

Besik Kochlamazashvili

The aim of study is immunomorphologic investigation of regular (conventional) and Germfree (gnotobionts) white rats during aging. The results of study showed that generally spleen lymphoid tissue of gnotobionts unlike conventional ones don't reduce during aging. In follicles, despite of simplifying antigenic loading, has been increased (in comparison with the control) phagocytic activity, enhancing with the aging process. Has been indicated aging increasing of T-lymphocytes' number on the background of unchanged number (comparing with the control, not depending on age) of B-cells. So, Immunopoiesic potential of gnotobionts' spleen depends not so as on the influence of "external" antigenic stimulus as on the influence of "internal" (processes of depo and hemokatharsysis) factors, creating "local" conditions for antigenic stimulation of organ.

Keywords:   gnotobionts, spleen, immunomorphology, aging