Osmotic Resistance of Erythrocytes in Obese Patients

Nestan Merkviladze, Eka Rapava, Nino Tkhilava

Obesity, type 2 diabetes mellitus, cardiac ischemic disease, atherosclerosis and hypertonic disease all are united into one syndrome which is characterized by the resistance to insulin. The goal of the work was to study osmotic resistance of erythrocytes in order to give a complete picture of obesity pathogenesis during this pathology. Total of 38 obese patients - 25 female and 13 male (IBM 25-30) - as well as 10 healthy persons (IBM 20-24) were investigated. Osmotic resistance of erythrocytes was studied according to the kinetics of the lysis. From the analysis of data obtained it is ascertained that in obese patients of the both sexes osmotic resistance of erythrocytes is reliably decreased as compared to the control group. According to the data of literature and also to our results, it may be supposed that disorders of lipid exchange and haemorheological shifts accompanying the obesity are also reflected in the structure of membrane. This conditions a rapid spherulation of erythrocytes and precocious hemolysis, what points to osmotic resistance.

Keywords:   obesity, osmotic resistance of erythrocytes, diabetes mellitus type 2