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The course of pregnancy in 6-8% cases is complicated by preeclampsia, and every year it is responsible for about 50000 maternal deaths all over the world. Etiology of preeclampsia is unknown. Currently the following hypotheses related to the etiology of preeclampsia are popular: a) placental ischemia; b) endothelial dysfunction; c) immunologic maladaptation; d) genetic and e) elevated peroxide oxidation of lipids. Abnormal invasion of trophoblast when spiral arteries are replaced by trophoblast is considered as one of the major pathogenetic factors in the pathogenesis of preeclampsia. Placental apoptosis was indicated as the cause of abnormal invasion of trophoblast in several papers. Recently intensive studies to investigate the phenomenon of "cellular suicide" have been carried out. Apoptosis is involved in the development of widely spread diseases. There are data indicating that the onset of preeclamsia is always accompanied by apoptosis. We believe that apoptosis may become a key possibly to several locks hiding the secrets of preeclampsia pathogenesis.
Keywords:
preeclampsia, placental apoptosis, trophoblast invasion
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