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The condition of the basic components of antioxidant-prooxidant system and the role of revealed disturbances in origin and progressing of the endogenic intoxication syndrome (EIS) were estimated. Three components of EIS were investigated: the toxemia, the tissue hypoxia and the antioxidant protection. The level of average molecules in plasma and erythrocytes, ALT, AST, LDH, SOD, malonic dialdehyde, ceruloplasmine, catalase, glutathione reductase, glutathione peroxidase, lactate were studied by biochemical method; the biophysical parameters of blood, myocardium, liver, kidney by Electronic-Paramagnetic-Resonance methods. The disbalance between different links of antioxidant protection, insufficiency of major antioxidants, intensification of free radical oxidation, oxidative stress play a leading pathogenic role in EIS development during traumatic shock. Major sources of production of oxygen active forms are a mitochondrial respiratory chain, hypoxantine - xantineoxidase system, microsomal P-450 oxidase system, excess of Fe2+ ions, Mn2+ ions and NO. Oxidant stress can determine expressiveness of endotoxicosis and appearance of polyorganic insufficiency in presence of tissue hypoxia and energy-deficiency.
Keywords:
Endogenic Intoxication Syndrome (EIS), average molecules, ceruloplasmine, catalase, glutathione reductase, glutathione peroxidase, SOD, malonic dialdehyde, lactate, EPR, traumatic shock
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