Serotyping of Georgian Strains of H.pylori Based on Cytotoxin Producing Features (CagA and VacA) and the Role of Different Serotypes in the Development of Surgical Complications and Various Clinical Outcomes of PUD

Levan Labauri *, Nodar Lomidze *, Darejan Chikviladze **, Manana Lobjanidze **, Merab Buadze ***, 
Tina Kutubidze ***, Perez-Perez Guillermo Ignacio****

*#1 Department of Surgery, **Department of Microbiology, Virology and Immunology at Tbilisi State Medical University, Georgia;
***Pediatric Hospital of Tbilisi State Medical University, Georgia; 
**** Section of Medical Microbiology, Division of Infectious Diseases, 
New York University School of Medicine, USA

Several genotypes of VacA are associated with both different levels of cytotoxin activity and different clinical outcomes of complicated PUD. Recent studies from developed countries have suggested that the CagA and VacA genes are more prevalent among the strains of H.pylori isolates from the patients with PUD. On the other hand, reports from some authors from the regions like developing countries, have found no association between the presence of cagA and vacA and the clinical outcome of H.pylori infection. Have been studied 21 strains of H.pylori taken from 16 Georgian patients using PCR. The results of our study suggest similarity to those findings in the prevalence of cytotoxin productive (CagA and VacA) genes and clinical outcomes.

Keywords:   cagA, vacA, peptic ulcer disease, H.pylori