Interrelations of Neuro-Endocrinal Regulation and Intracranial Hemocirculation during Rheumatism in Adolescents

Salome Kavtaradze, Lali Gujabidze

Center for Mothers and Children, Tbilisi, Georgia

The present work was aimed to detect the correlation between cerebrovascular complications and noradrenergic-serotoninergic regulation disbalance in adolescents during primary rheumatism. Total of 20 adolescents (average age 10,2±1,3) with the primary rheumatism and subjected to antibiotic and non-steroid anti-inflammatory treatment have been investigated using the method of fluorometry and Intra-cranial dopplerography. Have been detected, that during the primary rheumatism, complications are frequently presented by the chorea minor; Norepinephrine content is significantly reduced compared to the group of practically healthy children; Epinephrine concentration increases, resulting decrease in Norepinephrine/Epinephrine interrelations; Accumulation of dopamine in brain structure makes background for aggressiveness, chaotic movement, emotionality etc; Increased serotonin concentration and decreased Norepinephrine/Epinephrine interrelations points on alterations towards serotoninergic regulation.

Keywords:  rheumatic disease, dopplerography, catecholamines, adolescents