Some Molecular Mechanisms of Different Stress Factors Influence on Process of Physiological Pregnancy

David Gagua, Jaba Gamrekelashvili, Nikoloz Kintraia

As it is known in case of complications at pregnancy, homeostasis is disturbed, takes place hypoxia, intensification of oxidative process, changes in NO metabolism, often having undesirable effect as on mother organism as well as on fetus. Due to the above-mentioned the aim of our study is the investigation of free radical oxidation and NO metabolism processes during the influence of different stress factors on body at the experiment. It can be concluded that antioxidative system of blood is very sensible to the changes of metabolism, taking place at pregnancy. At the physiology of pregnancy activities of SOD and catalase responses are higher while at gestosis activity is increased sharply and activity of glutationreductase is reduced. The revealed regularities indicate reduction of blood antioxidant enzymes ability to response on intensification of free radical oxidation at pathological pregnancy.

Keywords:  pregnancy, glucose-6-phosphatdehydrogenase, superoxiddismutase, catalase, glutationreductase