Favorable Effects of 24 Hour-Infusion of Magnesium Sulphate in AMI on Early and Long-Term Outcomes of Disease

Mamuka Kobalava, Nikoloz Andriadze

The aim of the study was to evaluate influence of 24 hour-infusion of magnesium sulphate on early and long-term outcomes in patients with Acute Myocardial Infarction (AMI). Patients were divided into two groups. In the study group they received magnesium sulphate in combination with traditional therapy (beta blockers, antiagregants, anticoagulants, nitrates) versus the control group, where patients received only traditional therapy. The favorable clinical effects were mentioned in the study group compared to control resulted in reduction one month and six-month mortality, rapid positive dynamics of ST segment changes. According to ultrasonography after a week of treatment segmental contractility improved mildly in the study group. The favorable advantage was seen at the end of the first month and especially by the end of six month.

Keywords:  acute myocardial infarction (AMI), mortality, ejection fraction, VCF, hibernation