The Changes of pH and Partial Pressure of Oxygen in Blood at Chronic Heart Failure

Nino Mamamtavrishvili*, Giorgi Red'ko**, Gulnara Tabidze*, Marina Iakobashvili*

Disorders in myocardium metabolism taking place at heart failure are connected with reduced blood supply and promote decrease of ATP production, breaking of oxygen consumption, increase of lactate and hydrogen ions' production. In this connection study of changes of partial pressure of oxygen ions occurring in blood of patients with systolic and diastolic forms of heart failure seems to be of great interest. On the basis of obtained results it should be concluded that at systolic and diastolic forms of heart failure the development of acidosis and decrease of partial pressure of oxygen ions in blood take place. Due to all the above mentioned the disorders of metabolic processes and decrease of oxygen consumption develop in tissues, making preconditions for development of organism's antioxidant system insufficiency, activation of free-radical oxidation and progress of oxidative stress in the organism.

Keywords:  oxygen ions, partial pressure, blood pH, chronic heart failure, free radical oxidation, oxidative stress