Clinical and Immunological Aspects of Treatment of Acute Herpetic Stomatitis with Plaferon-Containing Adhesive Films

Nato Korsantia,* Alexander Katsitadze,** Vladimir Bakhutashvili,* Nino Korsantia***

The plaferon-containing adhesive films were attached to mucous lesion of patients with acute herpetic stomatitis (plaferon - preparation received from human placenta, which possesses immunomodulating, antihypoxic and desintoxicative effects). Analysis revealed the improvement of clinical indices on 3-5 days earlier than in control group of patients. It is very important, that films do not evoke local irritate and allergic influence on hard tissues of tooth, periodontal and mucous membrane of oral cavity. Initial quantity of lyzocyme and SIgA in saliva was decreased and was depended on severe and form of pathology. After plaferontherapy rapidly activation of these parameters occurred and the normalization was achieved on 7-10 days of treatment. We consider the expedient of wide using of plaferon-containing adhesive films in dermatology because of a great therapeutic and local immunomodulating effect and prolonged action.

Keywords:  plaferon, adhesive films, herpetic stomatitis, immune homeostase