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Critical state of any genesis is accompanied with activation of free radical processes in tissues and organs of patient. The aim of the study was investigation of the pathogenesis of critical states on subcellular, molecular level. We've decided to investigate state of adrenoreceprors of blood cells and metabolism of free nitric oxide. In the blood EPR spectrum has been revealed decrease of signal, characteristic for activated form of adrenoreceptors and increase for their inactivated form. During the critical state the content of nitric oxide (NO) in blood increases sharply as well. It can be concluded that oxidative stress is very important pathogenetic factor of critical state development. Over-intensification of free radical processes causes suppression of compensatory reactions in body, causing adrenergetic structures and nitrogen oxide.
Keywords:
calculates, ration of diet, practical feeding, substance changing, biochemical status
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