Effect of Plaferon LB in Ischemia/Reperfusion of the Pancreas

Rusudan Rukhadze, Tamar Sanikidze, Malkhaz Mirtskhulava, Manana Papava

The aim of the present study was to find out whether plaferon LB, a well-known antioxidant and membrane stabilizer could be applied in pancreas preservation for protection pancreatic tissue from cell damage, which occurs during ischemia/reperfusion. To evaluate the protective effect of plaferon LB part of animals received widely used protectors a tocopherol, unithiol and vitamin C. According to received data plaferon LB appears to protect the pancreas from ischemia reperfusion injury by reducing the peroxidation of the pospholipids and maintaining the activity of SOD more effectively, than a tocopherol, unithiol and vitamin C together.

Keywords:  pancreas, ischemia reperfusion, plaferon LB