Pro- and Antioxidant Systems' Changes of Blood in Patients with Diabetic Angiopathy

Nika Navadze, Ivane Datunashvili

It is known that in the pathogenesis of development of diabetic angiopathy the big role plays free radical interrelations. That is why we studied Pro- and antioxidant systems' changes of blood in patients with diabetic angiopathy before and after traditional treatment by the method of the electro paramagnetic resonance. The received results show that in investigated patients' blood was supervised the surplus of free-radical interrelations on the background of the law activity of anti-oxidant protection enzymes. The level of NO is law in blood which is provoked by the forming peroxinitrate intensively and also by forming the HbNO complexes. On the background of traditional treatment was not investigated the important improvement of analyzed parameters.

Keywords:  diabetes mellitus, angiopathy, nitric oxide, metHb, free radicals