The Investigation of Pharmacological Peculiarities of Bludiabin on Experimental Model of Insulin-depended Diabetes Mellitus

Manana Esaiashvili, Irakli Chkhikvishvili, Maia Gagua, Marina Machvariani, Ivane Datunashvili

Progressing the insulin-depended diabetes mellitus maintains the further destruction of β-cells that is partly caused by the high level of glucose in blood representing the most important factor of diabetical complications. Due to this fact, to find the regulating preparations of glucose in blood is of great importance. The aim of our study is the investigation of Bludiabin and Plaferon LB, native preparations (agents) at experimental alloxan diabetes. The experiments have been carried out on white rats. To induce the insulin diabetes, the animals were injected by alloxan. Pancreases tissue micromorphological changes were studied. Studying the structure of egzogenic part of pancreas on rats affected with alloxan diabetes has been shown the prevalence of connective and fat tissues. In some sites the existence of periductoral necrotic areas was noticed. Definite part undergone structural and atrophic changes. Plethora of blood vessels system was revealed. Obtained results show that the preparations: Bludiabin and Plaferon LB protect pancreatic tissue from injuries with alloxan and promote the restoration of its functioning that is revealed by normalization of glucose level in blood, reduction of oxidative processes and maintaining the antioxidant enzymes activities.

Keywords:  insulin-depended diabetes, beta-cells, hyperglycemia, Bludiabin