Study of Protective Action of Plaferon and Phenowine on Some Indices of Experimental Influenza in White Mice

Maia Johnson, Andrey Chilaia, Teimuraz Koridze

The main purpose of our investigation was to study action of influenza virus on several immune indices, its mutagenic and embriotoxic effects in white mice, and evaluate a potential protective effect of plaferon-LB and phenowine. These preparations were highly successful in reversing immunosuppression, caused by influenza virus. Results of immunocorrective therapy proved, that heterologous plaferon demonstrated strong protective action in white mice. Plaferon/phenowin-therapy resulted in fewer aberrant metaphases of chromosomes (12,8% vs. 36,3% in the control of virus). In general, the protective effect of preparations was manifested as a decrease in the number of isolated aberrations, as well as a reduction in lysis of chromosomes. An antiembryotoxic effect of plaferon with improvement in indices of preimplantation mortality of fetus (from 13,1% to 8,8%) and total prenatal mortality of fetus (from 19,6% to 15,1%) were showed. These characteristics of plaferon and phenowine, observed in our clinical investigations and experimental study in white mice, serve to justify the use of these preparations in prophylaxis and treatment of influenza.

Keywords:  influenza virus, plaferon, phenowine, immunocorrection, mutagenic/embriotoxic effects