Evaluation of Efficiency of Various Methods of Interruption of Pregnancy in II Trimester

Archil Khomasuridze, Maia Parcauli

The work was aimed to evaluate efficiency of interruption of late pregnancy with the use of anti-progesterone. Has been used the Russian analogue of mifepristone - "Penkrofton" (company "Penkroft-Farma"). Penkrofton was tested on 102 women with gestation period ranged from 14 to 22 weeks. The control group was consisted of 80 pregnant women, who were subjected to intra-amniotic infusions of 20% sodium chloride solution. Among these 102 patients 90 had spontaneous motor activity of uterus. In 11 cases additionally were used prostaglandin E1-mizopristol 200 mcg x 2 tab. In one case, as a result of congenital abnormality (acrania, 17 to 18 weeks) surgical abortion of fetus was performed. The clinical effect in case of Penkrofton mono-therapy was 87,2%, and in case of combined therapy with Penkrofton and prostaglandin E1 - 19,6%. According to the results of investigations could be concluded that interruption of the late pregnancy (according to medical indications) with the use of Penkrofton is the simple, safe and quite efficient method for artificial interruptions of pregnancy. Therefore, it could be considered as the optimal method.

Keywords:  reproductive function, pregnancy, abortion, antiprogesterone, prostaglandins