The Influence of Body Mass on Blood Nitric Oxide Values in Patients with Metabolic Syndrome

Nino Eloshvili, Manana Koplatadze, David Virsaladze, Eldar Imedidze

Department of Endocrinology, Tbilisi State Medical University, Georgia

The redox-system imbalance related to free-radical nitric oxide (NO) data plays a considerable role in the development of cardiovascular diseases. Our aim was to investigate body mass influence on NO values in patients with metabolic syndrome. 86 Patients with metabolic syndrome were investigated. Body mass index (BMI), waist circumference, glycemic and blood pressure (BP) data were determined. Blood NO concentration was estimated using the electronic-paramagnetic resonance (EPR) method by NO EPR signal intensity. The patients were divided into 4 groups: group I – normal body mass (BMI=18,5-24,9 kg/m2), group II – overweight (BMI=25,0-29,9 kg/m2), group III – obesity (BMI=30,0-34,9 kg/m2) and group IV – obesity (BMI і 35,0 kg/m2). According to our results NO decrease was significant in both groups of obese patients No.3 and No.4 in comparison with normal body mass group I (p1-3=0.009 and p1-4<0.001, respectively). NO EPR-signal significantly differed between groups III and IV (11.7±2.8 и 9.5±2.4 mm/mg, respectively; p=0.008). In all 4 groups NO data were significantly lower in comparison with the control group parameter. In the whole contingent BMI correlated inversely with NO (r=-0.462, p<0.001). The similar relation was found out between waist circumference and NO (r=-0.301, p=0.049). In the groups divided by BMI waist circumference, systolic and diastolic BP were increasing parallel with BMI increase, and were significantly higher than the analogous parameters of the control group.

Keywords:  metabolic syndrome, nitric oxide, obesity, body mass