Effect of Antioxidants and Membrane-Stabilizing Drugs on Paraneoplastic Disorders of Erythrocytes and Microcirculation

Ketevan Gambashidze, Vakhtang Kipiani

Department of Pathophysiology, Tbilisi State Medical University, Georgia

Has been investigated the intensity of local hemocirculation, functional state of adrenoreactive structures of mesenteric blood vessel walls and erythrocytes' deformability (ED) in mice and rats during experimental malignant tumor growth (Ehrlich carcinoma, Walker carcinoma, Sarcoma C-45) before and after treatment with antioxidants and membrane-stabilizing drugs, with the use of H+ clearance, bio-microscopy, pharmacological analysis using the vasoactive agents, and filtration-photometry methods. The received data were analyzed statistically by means of Student's criterion. Has been stated that during the process of experimental malignant tumor growth the local hemocirculation and erythrocytes' deformability are decreased, the functional state of adrenoreactive structures of mesenteric blood vessels is impaired. At the early stage of cancer growth the malfunctioning of a-receptors is expressed; at the late stage of malignant growth both, functional state of a- and b-receptors are impaired. Administration of antioxidants and membrane-stabilizing drags markedly improved the above-mentioned disturbances. Revealed improvements after treatment with antioxidants indicates the leading role of peroxidative processes in pathogenesis of paraneoplastic disorders of erythrocytes and microcirculation.

Keywords:  cancer, paraneoplasia, erythrocyte, deformability, adrenoreceptors, alpha-tocopherol, proxanol P-268, plaferon LB