Parameters of T-, B-lymphocytes and IL-6 during Gastroduodenal Diseases Caused by Helicobacter Pylori

Nana Gabadadze

Iv. Javakhishvili State University Therapeutic Diagnostic Center Department of Clinical Laboratory Diagnostics of State Medical Academy of Georgia

Helicobacter pillory (H.P.) induced immune reactions play leading role in the damage of gastroduodenal zone mucous membranes. At the same time it is known that cytokines production by peripheral blood cells has some influence on the stomach epitheliocytes and development of inflammatory process in stomach membranes. Proceeding from the above mentioned we aimed to investigate peripheral blood T-, B-lymphocytes and IL-6 during gastroduodenal diseases. We have observed patients with ulcer disease (20), chronic gastroduodenal disease (32 patients) and mixed form of ulcer and chronic gastroduodenal diseases (37 patients). There was no difference found between groups while comparing quantities of T- and B-lymphocytes, T-suppressors. The active fraction of T-lymphocytes was statistically reliably decreased in the mixed group in comparison with the chronic group. It should be mentioned that there is a tendency of T-active lymphocytes increase in the group of patients with chronic course of disease in comparison with all other groups. IL-6 concentration in peripheral blood was the highest in the chronic group. Accordingly, there is increase in T-active and T-helper lymphocyte quantity, as well as IL-6 concentration in peripheral blood during chronic gastroduodenal diseases. All the above-mentioned give us opportunity to conclude that quantitative determination of T-lymphocytes subpopulations and IL-6 is significant factor for diagnosis of chronic forms of gastoduodenal pathology.

Keywords:  helicobacter pylori, T- and B-lymphocytes, IL-6