Study of Pharmacological Properties of Plaferon LB on the Experimental Model of Insulin-dependent Diabetes Mellitus

Marika Gamkrelidze, Rusudan Rukhadze, Ivanе Datunashvili

The experimental Institute of Morphology, Tbilisi, Georgia

Insulin-dependent diabetes mellitus (IDDM) is characterized by selective destruction of insulin-producing islet beta cells. Reactive free radicals act as intermediates in cytokine-induced destruction of beta-cells. Present study investigated effect of the preparation plaferon LB on morphological changes in pancreatic islets caused by experimental diabetes in rats. Study of H&E sections revealed marked histological changes in pancreatic tissue from the control diabetic group animals, whereas in animals from the plaferon LB treated group signs of periductal necrosis have not been found; atrophied areas occurred, though they were rare; fat infiltration has not been observed. This experiment has manifested that plaferon LB significantly reduces pancreatic tissue lesions induced by alloxan. Due to its ability to inhibit the synthesis of proinflammatory cytokines and the production of free radicals plaferon LB acts as a protector of insulin-producing beta cells and contributes to the regulation of blood glucose level.

Keywords:  insulin-dependent diabetes mellitus, islet beta cells, plaferon LB