The Role of Immune Disorders in Development of Skin Demodecosis

Lela Beridze, Alexandre Katsitadze

Department of Dermatology and Venerology, Tbilisi State Medical University, Georgia

According to the modern data a skin is considered as a compound part of immune system, that is why processes which take place in the epidermis and derma are reflected on common immune response of constitution. Demodecosis is a chronic disease; predominantly it tends to affect facial skin and is caused by cutaneous infection with the mite-demodex folliculorum. Immunological parameters were studied in 20 patients with skin demodecosis. From them 14 were females and 6 males at the ages from twenty to sixty. Duration of course was 1-4 years. According to the received data it was established, that patients with skin demodecosis have serious depression of both - systemic and local immune parameters. They have low level of several immunological parameters: T- lymphocytes (T- helper, T- suppressors), index of phagocytosis, especially alpha and α interferon. Depression of immune homeostasis is parameters was observed, with correlation to hardness of process.

Keywords:  skin demodecosis, demodex folliculorum, immune homeostasis