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We have researched the men ill with prostate cancer, the age of whom didn't exceed 70 years (19 cases) and the patients, the age of whom was more than 70 years (22 cases). The research was made before castration and after 6 months from the castration. On the basis of analyze of laboratorial data, it was made clear, that the concentration of testosterone, as well as the quantity of prostate-specific antigen was not much differ in different age groups. For example, in the plasma of blood of the patients under 70 years, concentration of testosterone was equal to 36,65±5,4 nmol/L, and the concentration of prostate-specific antigen was 26,62±20,3 ng/ml and in the blood of patients above 70 years these indices accordingly consisted of 36,4±2,2 nmol/L (testosterone) and 31,42±10,3 ng/ml. After castration, the indices of testosterone in the plasma of blood in the patients were reduced in both cases. In case of patients under 70 years, concentration of testosterone was reduced to 5,9±3,2 nmol/L, and in the plasma of blood of the patients above 70 years to 6,42±2,2 nmol/L. In spite of it, statistically reliable changing in the quantities of prostate-specific antigen was reduced to 17,38±1,33 ng/ml and in the plasma of blood of patients over 70 years to 21,47±15,3 ng/ml. Thus, from the gained data it makes clear, that the quantities of testosterone, as well as prostate-specific antigen don't differ in the blood of patients under and above 70 years. In both cases, castration causes the reducing of quantities of testosterone and prostate-specific antigen, but their changing was not found out to the age.
Keywords:
prostate cancer, prostate-specific antigen, testosterone, age groups
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