Effect of Duodenides on Animals' Alimentary Behavior

Darejan Mzhavanadze, Archil Asatiani, Irina Kvachadze

Department of Physiology, Tbilisi State Medical University, Georgia

The aim of this study was the evaluation of animal's alimentary behavior under the influence of biologically active substances, existing in duodenal extract. Have been carried out the experiments on white rats of Wister's rule, the mentioned rats previously were left in food deprivation of 48 hours' duration. They were injected intra-abdominally with 1,5-2,0 ml of mucous extract of duodenum, prepared before the experiment started and approximately in 10-15 minutes the rats were fed. Have been observed the targeting behavioral responses. The daily moving activity (in Richter-Yang apparatus) and also the amount of used food was defined. Essential inhibition of food-getting behavioral reaction (for 9-10 min) and their low activity expresses the inner state of animal but it still is not the index, indicating to suppression of alimentary motivation. However, the sharp decrease of used food (by 11,5%) and moving activity (by 45%) indicate to the presence of appetite-regulating biologically active substances in duodenal extract influencing on alimentary behavior.

Keywords:  alimentary behavior, duodenum, duodenides