Thermal Characteristics of Blood in Early Age Children with Pneumonia

Marine Bochorishvili*, Manana Khochava*, Shota Barbakadze**, Lida Mchedlishvili**, Michael Gadabadze**

*Department of Children's Infection Diseases, Tbilisi State Medical University, Georgia;
**Department of Biopolymer Thermodynamics, E. Andronikashvili Institute of Physics, Academy of Sciences, Georgia

A comparative analysis of thermal properties of the whole blood, erythrocytes and blood plasma of healthy and sick with pneumonia children at the age from three months to five years has been carried out for the first time. It has been shown that 3 endotherms at 60.5°C, 70°C and 80°C are observed in the heating process of healthy child whole blood on the thermogram and in case of pneumonia only one endotherm at 70 0C is observed. It has been established that the endotherm at 60.5°C appears due to denaturation of albumin fatless fraction, and the endotherms at 70°C and 80°C - due to denaturation of erythrocytes. It has been also shown that denaturation heat (Qd) coming on endotherm at 60.5°C in case of plasma denaturation of child with pneumonia is 5 times less than Qd coming on this endotherm in case of norm. This result directly points that a content of albumine fatless fraction in case of pneumonia in comparison with norm is decreased by 5 times. An observed decrease of endotherm Qd at 70°C in case of plasma denaturation and an absence of endotherms at 60°C and 80°C in case of whole blood denaturation of child sick with pneumonia is used as a new, quick, reliable and cheap test for diagnostics of the protein disorders in case of pneumoniae.

Keywords:  severe pneumonia, children, differential scanning microcalorimetry