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The present work discusses methods of goal-directed immune-correction and immune-rehabilitation of oncological patients using specific bacterial polyvalent vaccines. With this purpose the tetra-vaccine (Staphilococcus-Proteus-Clepsiela-Escherichia) has been used. Experiments have been carried out on white rats and mice with the use of three tumoral strains - Sarcoma-45, Sarcoma M-1 and Ehrlich's ascitic tumor. For chemotherapy of malignant tumors the following remedies were used: Cyclophosphan, Vincristin and Adriablastin. The vaccine and chemotherapy were applied in both ways, separately (control), and in combination. The results of investigations have shown that the best effect was achieved in case of combination of vaccine with chemotherapy - malignant tumors completely underwent regression, while using only tetra-vaccine, the percent of malignant tumor growth inhibition constituted only 37,6%. Thus, the received results are quite encouraging and the above-suggested method could be used for treatment of oncological patients.
Keywords:
cancer, vaccination, chemotherapy, bacterial vaccine
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