Influence of Hypersecretion of Testosterone on Lipid Metabolism

Mikheil Sabakhtarashvili, Leila Bregvadze, Barbare Gorgoshidze, Nanuli Petriashvili 

Zhordania Institute of Human Reproduction, Tbilisi, Georgia;
Chair of Reproductology, State Medical Academy, Tbilisi, Georgia

The aim of our study was to evaluate the influence of hypersecretion of testosterone on lipid metabolism. Observational cross-sectional study was carried out. 62 women, selected by randomization, aged before 30 years, were investigated. Clinical, ultrasound, hormonal investigations were carried out. The markers of lipid metabolism – TC, HDL, LDL, VLDL, TG, I.AT were defected as well. According to our results testosterones, one of the powerful androgen, is characterized with atherogenic effect and realized by elevation of levels of TC, LDL and I.AT. In cases of oversecretion of both DHEAS (androgen of adrenal origin) and T, their opposite effects towards, lipid metabolism are balanced and lipid parameters didn’t differ from normal, physiological values.

Keywords:  lipid metabolism, free testosterone, dehydroepiandrosterone sulfate