Morphological Investigation of the Nucleus of White Blood Cells at Opiate Dependences and also in Case of Naltrexon Application as an Opiate Antagonist

David Vadachkoria, Luiza Gabunia 

Department of Pharmacology, Tbilisi State Medical University, Georgia

Have been investigated the white blood cells of 20 patients, suffering from opiate dependence. Morphological changes of nucleus were detected using the electronic microscope. Investigations have shown that application of opiate antagonists at treatment of opiate dependences is justified from morphological point of view, since it leads to certain positive clinical effects. Administration of naltrexon in the period of remission relatively increased the area of euchromatin and widened perinuclear halo; nuclear clasmatosis was poorly expressed; edges of nucleus were even. On the background of naltrexon application, the nucleus was lesser repressed. However, it must be mentioned that suggested method of treatment does not provide complete recovery and perfect functioning of the cells.

Keywords:  naltrexon, opiate dependence, euchromatin-heterochromatin, clasmatosis, perinuclear halo, pathological homeostasis