Effect of alpha-tocopherol on redox-status alterations and
paraneoplastic disorders of erythrocytes

Ketevan Gambashidze

Department of pathophysiology, Tbilisi State Medical University, Georgia

Have been investigated erythrocytes' membrane resistance (ER), deformability (ED) and electronic-paramagnetic signals of blood and liver tissue of white rats (weight range 220-250 g.) during Walker carcinoma growth before and after treatment with a-tocopherol with the use of methods: spectrophotometry, filtration-computed photometry and electronic-paramagnetic resonance (EPR). Investigations have shown paraneoplastic alterations of redox-potential of blood and liver tissue, disorders of mitochondrial respiration and activity of antioxidant processes, exaggerated lipid peroxidation (POL), reduced ER and ED, altered processes of detoxication. Important role of redox-potential disturbances in paraneoplastic disorders of erythrocytes membrane is confirmed by positive influence of antioxidant and membrane-stabilizing therapy. After treatment with ?-tocopherol the above-mentioned disturbances vividly were reduced.

Keywords:  cancer, paraneoplasia, erythrocyte, deformability, resistance, alpha-tocopherol