Effect of plant preparations on the intensity of weight gaining and lipid metabolism parameters during experimental alimentary obesity

Tea Chanadiri, Medea Sikharulidze, Manana Esaiashvili, Irakli Chkhikvishvili, Nino Tkhilava, Eka Ekaladze, Maka Machavariani

Institute of Medical Biotechnology of Georgian Academy of Science;
Tbilisi State Medical University, Georgia

In contemporary literature there are data about significant role of free radical oxidation in the pathogenesis of obesity. In this relation application of endogenous as well as exogenous antioxidants for the purpose of excess weight correction has generated increasing interest in scientific circles. Numerous researches showed natural antioxidants to be effective in correction of elevated blood cholesterol, triglycerides, LDL levels. In this relation the purpose of our research was to establish effectiveness of green tea catechines and citrus extract on lipid metabolism disorder and excess body weight during experimental alimentary obesity. Experiment was conducted on rats kept on high-calorie diet for 7 weeks. Simultaneously animals from III and IV group had been administered catechines and citrus extract at the doses of 15 mg and 30 mg respectively in addition to the high-calorie diet during last 4 weeks. The experiment established corrective effect of abovementioned preparations on the parameters of lipid metabolism (blood cholesterol, triglyceride and LDL levels) and epididymal fat mass. It appeared that citrus extract is especially effective to hinder in weight gain. Obtained results are very important and may be used for the development of weight losing diets.

Keywords:  alimentary obesity, diets, lipid metabolism, free radilcals oxidation