Effect of carvedilol and nebivalol combination on experimental rabbits’ blood rheology and platelets’ aggregation-adhesion on the background of electrical distress

Luiza Gabunia, Tamar Vardosanidze, Levan Ratiani, Vladimer Janiashvili,
Tamuna Changelia, David Vekua, David Vadachkoria

Department of Pharmacology, Tbilisi State Medical University, Georgia

Nowadays in pharmacotherapy of cardiovascular diseases the beta-blockers of third generation – carvedilol and nebivalol (with vasodilatatory effects) are used successfully. In the present work has been shown effect of combined administration of carvedilol and nebivalol (ratio 3:1) on certain indices of blood rheology and platelets’ aggregation-adhesion in experimental rabbits on the background of electrical. Has been stated that combination of carvedilol and nebivalol (ratio 3:1) decrease indices of platelets’ aggregation-adhesion, and activity of various parameters of coagulation system. This fact is very important in pharmacotherapy of various cardiovascular diseases, especially in case of treatment of ischemic heart disease and patients with manifested coronar syndrome, hypercoagulation and platelets’ increased aggregation-adhesion. Combined administration of carvedilol and nebivalol in case of electrical distress (according to the results of previous investigations and present study) efficiently improves blood rheology and effect is much better than in case where the same preparations are used separately.

Keywords:  beta-blocker, carvedilol, nebivalol, prothrombin index, fibrinogen concentration, beta-fibrinogen, platelets’ aggregation-adhesion, erythrocytes’ osmotic resistance, electrical distress