Effect of dilatrend and metoprolol on certain parameters of hemocoagulation system

Shalva Petriashvili, Luiza Gabunia, Betusha Vasadze, Tamar Vardosanidze, Nino Ganugrava

Scientific Research K.Chachava Institute of Perinatal Medicine and Obstetrics and Gynecology, Tbilisi, Georgia;
Department of Therapy, Tbilisi State Medical University, Georgia

We were aimed to study effect of the third generation -blockers - metoprolol and dilatrend (in vitro) on the following parameters of hemocoagulation system in patients with ischemic heart disease: ATIII, time of blood coagulation, time of partial thromboplastin, time of recalcification, prothrombin index, time of thrombin, fibrinogen concentration and fibrinolytic activity of blood. According to the results of investigation dilatrend and metoprolol revealed positive effect on plasma factors of hemostasis compared to the control. Dilatrend was especially efficient that was manifested by increased ATIII activity, time of blood coagulation, recalcification and thrombin. As for fibrinolytic activity of blood and fibrinogen concentration they were decreased that was better expressed 1 month later from beginning of treatment. Reveled Changes were statistically significant. Thus, dilatrent, along with other therapeutical effects revealed positive effect on hemocoagulation system that probably determines its high efficacy in pharmacotherapy of cardiovascular diseases.

Keywords:  newborn dilatrend, metoprolol, antithrombin III (AT III), hemostasis, prothrombin index, time of thrombin, time of activated thromboplastin, fibrinolytic activity