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The role of oxidative
stress in pathogenesis of neonatal sepsis in preterm infants
Nino
Sanodze, Nugzar Uberi, Manana Zhvania
Department of Specialization in
Pediatrics, Tbilisi State Medical University, Georgia
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Literature datas confirm the important role of free radicals of nitrogen and
oxygen in mechanisms of cells’ and tissues’ disorders at neonatal sepsis.
Derangements of intracellular oxidation-reduction balance disorder functioning
of cells and thereby result in homeostatic alterations and development of
oxidative stress in organism. In previous works have been shown that intensity
of oxidative stress at neonatal sepsis is especially high in preterm infants.
The aim of our work was investigation of changes of oxidative metabolism indices
in preterm infants after course of antisepsis therapy. As the results of
investigation have shown, carried out antioxidant and detoxifying therapy does
not provide significant decrease in intensity of free radical oxidation
processes. These circumstances interfere with improvements of neonates’ clinical
state.
Keywords:
free radicals, preterm infants, sepsis,
nitric oxide, oxidative stress, antioxidants
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