The study of streptokinase efficiency dependent on period of usage in patients with acute myocardial infarctions

Sophio Svanidze, Rusudan Napetvaridze, Irma Mamatsashvili, Tamar Emkhvari

#3 Internal Medicine Department of Tbilisi State Medical University, Tbilisi, Georgia

The aim of our work was the study of influence of thrombolysis on the course of acute myocardial infarction on hospital stage according to the beginning of treatment. Thrombolyitic therapy with streptokinase (SK) was carried out on 120 patients with acute myocardial infarction in cardiological department of #1 clinic of TSMU. Patients received intravenous thrombolytic treatment with 1,5 MU SK during the first 6 hours after infarction. Outcomes of carried out research showed that earlier application of thrombolyitic therapy (before 3 h) is more efficient, which was proved by cessation of pain, appearance of CPK high activity in most of I group patients. Ejection fraction of left ventricle is higher in the I group, though difference between I and II groups is not statistically significance. 30-days mortality was significance low in the first group and equaled to 6,4% in comparison with 11,9% in the second and 16% in the III group. 5-year mortality did not differ much in both groups.

Keywords:  myocardial infarction, thrombolithic therapy, reperfusion, mortality