Clinical controlled study of ascancol: effect on atopic dermatitis

Natia Mgeladze, Rusudan Karseladze, IngaDadeshidze, Gouram Tsagareishvili, Khatuna Khojava, Nino Tsagareishvili

Iv. Javakhishvili State University, Tbilisi, Georgia;
I.G Kutateladze Institute of Pharmacochemistry Georgian Academy of Sciences;
Scientific Research Institute of Pediatrics, Tbilisi, Georgia

The aim of our study was to evaluate clinical efficacy of ascancol in patients with atopic dermatitis (AD). The study was designed as open-controlled. Two matched groups of patients received the local treatment (monotherapy) with the ointment ascancol and with other semisolid medicinal forms (OSMF) for external use (hormonal, symptomatic indifferent ointments). All patients underwent a 3-9 months (catamnesis) run-in period, to assess their baseline conditions. Eighteen (80) patients with AD were investigated. From them 40 patients had undergone the local treatment with ascancol (monotherapy) and 40 patients were treated with OSMF for external use. Eighteen (80) patients, fulfilling the generally accepted diagnostic criteria of Hanifin and Rajka for the diagnosis of AD, who consecutively attended department of Clinical Allergology and Immunology of Institute of Pediatrics (median age of patients was 2 years—6 months-14 years) and “Asthma-school”- for allergic children and their parents (median age 37 years), were enrolled in this study; 50 male and 30 female concluded the study. Results of the investigation show us that ascancol causes positive changes in subjective indices, reflecting in antipruritic activity of the preparation and it is particularly important that, it clearly decreases such common objective indices, directly reflects dynamics of allergic process, as erythema and oozing. Generalizing results according to SCORAD index, in AD monotherapy with ascancol and with OSMF, according to comparison data of drying and antipruritic effects, ascancol is preferential than OSMF for external use, especially in early childhood.

Keywords:  atopic dermatitis, topical treatment, ascancol, bentonite gel