Relation of several indexes of endogenous protection system with neurological outcome on 14th day of ischemic stroke

Maya Beridze, Roman Shakarishvili, Revaz Lukava

Georgian State Medical Academy, Tbilisi, Georgia

Study purposed to evaluate several indexes of protection system in acute and sub-acute stages of ischemic stroke and to establish their relation with neurological outcome at 14th day. 95 patients aged 45 to 75 years, 54 female and 41 male investigated. Severity of disease evaluated by international scales GCS and NIHSS. Patients divided into three groups: 1st (27 patients) – with severe stroke (GCS>9, NIHSS>15), 2nd (39 patients) – with moderate severity (GCS=14-15; NIHSS=10-15), 3rd (29 patients) – with mild stroke (GCS=15, NIHSS<15). Again, all patients evaluated by NIHSS on 14th day of stroke. In 48 hours of symptoms onset and on 14th day blood levels of interleukine-10 (IL-10) detected by enzyme-linked immunosorbent assay and blood superoxidismutase levels (SOD) detected by spectrophotometric method. Results were processed by SPSS statistical computer packet. ANOVA analysis and multivariate logistic regression were used. IL-10 and SOD levels found significantly elevated on 14th day against initial indexes and control (p<0,05). 1st group revealed the decreased levels of IL-10 and SOD compared to 2nd and 3rd groups (p<0,05). Significant negative correlation found between IL-10 and SOD levels and NIHSS score at 14th day (r=-0,28 p<0,05 and r=-0,31 Sp<0,05 respectively). Apparently, stroke outcome significantly depends on activation of internal bio-protective.system.

Keywords:  interleukines, inflammation, penumbra, ischemia, protection