Modern problems of rheumatic diseases in children

Salome Kavtaradze, Lali Gujabidze

Center for Mothers and Children, Tbilisi, Georgia

Rheumatic diseases is a potentially debilitating autoimmune disease that affects approximately three percent of the population. The aim of the present study was to detect the correlation between cerebrovascular complications and noradrenergic-serotoninergic regulation disbalance in children during rheumatic diseases. The following changes were found in children with rheumatic disease and cerebral circulation disturbances: the increase of glutamate and aspartate, decrease of GABA, increase of catecholamines and serotonin in the blood. The ratio excitatory/inhibitory mediatory amino acids increased significantly. Disturbances of amino acids and biogenic aminoacids metabolism leads to the meurological complications of rheumatic diseases in children.

Keywords:  rheumatic disease, dopplerography, serotonin