Influence of some bacterial vaccines’ preventive anti-blastoma effects on experimental malignant tumor growth

Paata Khorava

A.Gvamichava Oncology National Center, Tbilisi, Georgia;
E-mail: paata_khorava@hotmail.com

The present work suggests goal-directed immune-correction and immune-rehabilitation of oncological patients with the use of bacterial vaccines. Have been studied preventive anti-blastoma effects of Proteus vaccine, Staphylococcus antitoxin and their complex divaccine on experimental malignant tumor growth. Experiments have been carried out on white rats (100-120 g) and mice (20-22 g.) with the use of strains - Sarcoma-45 and Ehrlich's ascitic tumor. The results of experiments have shown that in case of Ehrlich's carcinoma all three investigated groups on the background of reduced intoxication revealed increased percentage of mean life-span and consisted 14,4 day (18%), 16 day (31,7%) and 15.5 day (27%) respectively. In the same groups excessive body mass was detected by 41,5%, 47,4% and 40,2% respectively. In case of S-45, using the Proteus vaccine, animals’ life span was increased by 63% and by 22,4% - using the Staphylococcus antitoxin. In case of complex divaccination malignant tumors completely underwent regression during 32 –60 days after tumor inoculation. On the 40th day of immunization by complex divaccine malignant tumor did not develop in 77% of cases, while in remaining 23% of cases - tumor tissue was of minimal size (<1cm³) and animals life span 2,5 times exceeded the life-span of control group animals. Thus, the received results are quite encouraging and the above-suggested method could be used for treatment of oncological patients.

Keywords:  cancer, immunetherapy, bacterial vaccines