The experience at complex treatment of central nervous system prime malignant tumors with temodale

Guliko Papuashvili

A.Gvamichava Oncology National Center, Tbilisi, Georgia

Nowadays, the treatment of central nervous system prime malignant tumors is not satisfactory. Treatment with nitrosomethylurea and vincaalcaloid preparations is less effective. In last years interest of clinicians to medicament of new generation – temodale is increasing. Temodale is mainly used for treatment of malignant gliomas, multiform glioblastoma, anaplasic astrocytomas and brain metastasis as well. In oncology national center from May, 2002 year a total of 50 patients suffering from central nervous system prime malignant tumors underwent treatment with temodale. According to the histomorphology, brain medulloblastoma was detected in 13 of cases, glioblastoma – in 16 and astrocytoma – in 21 of cases. On the background of treatment with temodale initially the sharply expressed subjective effect was revealed, after 2-3 course – objective effects that has been confirmed by computed tomography. Among central nervous system tumors the astrocytoma is more susceptible to temodale and the treatment effect is much more effective than in tumors of other histomorphology. Chemotherapy with temodale is characterized by slightly expressed side effects (nausea, vomiting) that can be removed by cerucal or emetron.

Keywords:  central nervous system, malignant tumors, temodale, temozolomide(TMZ), astrocytoma, multiform glioblastoma, medulloblastoma